Monday, 5th February The 43rd Lorne Conference on Protein Structure and Function 2018
Breakfast
7:00AM - 8:30AM
Monday, 5th February
Lorne Central
Session 3: Protein assemblies #1
8:30AM - 10:30AM
Monday, 5th February
Auditorium
Chairs: Charlie Bond & Liza Cubeddu
- Ribosome rescue and homeostasis - Rachel Green
- Using small-angle X-ray scattering to screen for and classify biomolecular interactions - Po-chia Chen
- Investigating the effects of Lewy body components on the proliferation of alpha-synuclein aggregates - James W Brown
- Engineered receptors with a light switch - Harald Janovjak
Morning Tea/Coffee Break
10:30AM - 11:00AM
Monday, 5th February
Exhibition Hall
Session 4: Folding and quality control
11:00AM - 1:00PM
Monday, 5th February
Auditorium
Chairs: Diana Stojanovski & Ashley Buckle
- Folding and quality control of membrane proteins. - Elizabeth Miller
- Understanding how proteome foldedness changes under proteostasis stress - Dezerae Cox
- Exploring proteostasis through variation spatial states - William Balch
- Treating protein conformation diseases with small molecules - Jason Gestewicki
Lunch
1:00PM - 2:00PM
Monday, 5th February
Exhibition Hall
CryoEM Thermo Fisher Scientific Workshop
1:15PM - 2:45PM
Monday, 5th February
Auditorium
Sponsored by:
Session 5: Poster Session A including refreshments
4:00PM - 6:00PM
Monday, 5th February
Exhibition Hall
- A Paramagnetic peptide probe to guide the development of small molecule inhibitors of the AMA1/RON2 interaction - Mansura Akter
- Studying actin-tropomyosin interactions at the single filament level - Ilina Bareja
- A comparative study of Merlin against its paralogues, the ERMs. - Adam Bermeister
- Characterisation of chitin synthases from Fusarium graminearum - Linda Brain
- A Nightmare on EM Street: structural determination of the AAA ATPase Vps4 oligomer - Lou Brillault
- Re-targeting a bacterial assassin: Engineering PlyC specificity using directed evolution - Sebastian S Broendum
- Creation of Reporter Cell lines to identify and characterise tumour-derived Cachexia inducing factors - Zhipeng Cao
- Dynamin structure and function hinging on Ryngos - David A. Cardoso
- Investigating mechanisms of T cell Receptor activation - Nick J Chandler
- Engineering a non-antibody scaffold for binding to therapeutic targets - Peter G Chandler
- A surprise in the assembly mechanism of a cytokine receptor - Karen S Cheung Tung Shing
- Efficient hit to lead optimisation utilising a REFiL workflow - Beatrice Chiew
- The cytochrome P450s of Mycobacterium marinum and their electron transfer partners - Stella A Child
- Chemokine-Inhibiting Evasin Proteins Are Encoded Within Diverse Genera of Ticks - Sayeeda Chowdhury
- Structural and functional analysis of the C. elegans TRIM protein NHL-2 - Rhys N Colson
- Directed evolution as a tool for anticipating insecticide resistance - Galen Correy
- Probing the catalytic mechanism of N-acetylmannosamine-6-phosphate 2-epimerase from methicillin-resistant Staphylococcus aureus - Michael J Currie
- Structural and functional investigation of the tripartite ATP-independent periplasmic transporter family - James S. Davies
- The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis - Katherine A. Davies
- Development of novel AIEgens for protein carbonylation detection - Siyang Ding
- Selective inhibition of AMPK by a novel type II inhibitor - Toby Dite
- Recombinant expression of a problematic protein - Larissa Doughty
- Specific combinations of presenilin 1 protein regions are required for differential cleavage of amyloid precursor protein and notch receptor - Melissa Eccles
- Structural and biophysical characterisation of ssDNA binding by oxidised hSSB1 - Serene El-Kamand
- Reconstitution of phospholipid transport important for the maintenance of outer membrane lipid asymmetry in Escherichia coli - Bilge Ercan
- Unexpected role for newly identified small proteins in atrazine mineralisation - Lygie Esquirol
- Interchangeable regulatory domains: exploring modular allostery en route to chorismate - Yifei Fan
- Rational targeting of the Signal Recognition Particle Receptor - Camilla Faoro
- Novel functional roles of STAT3 regulating mitochondrial RNA stability and translational kinetics - Chamira Dilanka Fernando
- Exploring the physical and kinetic characteristics of citramalate synthase from Methanococcus jannaschii - Mohammad Firoozinia
- Characterisation of the human signal recognition particle protein component, SRP68/72, and its role in co-translational translocation - Janine K Flores
- Structural and biochemical characterisation of SARM Including mutagenesis analysis of tandem SAM domains and investigating auto-regulation of ARM domain - Xing Gui
- Beta-barrel assembly machinery (BAM) in action; a spatiotemporal characterisation using Single Molecule Localization Microscopy (SMLM). - Sachith D Gunasinghe
- Understanding the ATPase domain of the epigenetic regulator, SMCHD1 - Alexandra Gurzau
- Dynamic shifts of tubulins induced by Taxol - a proposed QENS study - Greger Hammarin
- Investigating the architecture of a Salmonella Typhi bacteriophage - Joshua M Hardy
- Bacterial sialic acid regulation - Christopher R Horne
- Insights into preferential heterodimerisation of human drosophila behaviour human splicing (DBHS) family proteins - Jie Huang
- Using in silico peptide exchange and alanine scanning to identify and characterize protein-protein interaction motifs - Sobia Idrees
- Homology modelling of ectopic olfactory receptors - amara jabeen
- Structural Studies of the Interaction of Gating Modifier Toxins and Voltage-gated Sodium Channels - Yan Jiang
- Engineering a C-mannosylation pathway into Pichia pastoris - Alan John
- Designer pentatricopeptide repeat proteins, a molecular spring in action. - Brady A Johnston
- Studying small heat shock proteins one molecule at a time - Caitlin Johnston
- Designing a magic bullet oncotoxin: manipulating the lewis antigen specificity of lectinolysin to target lewis y-associated tumours - Bronte A Johnstone
- Conformational sampling is altered during the emergence and evolution of new enzyme activity - Joe A Kaczmarski
- Irreversible inhibition of FGFR1 - Maria Kalyukina
- Elucidating the structural details of how hSSB2 binds ssDNA - Ruvini Kariawasam
- Empirical structural approaches to preemptively identify resistance mutations in Bedaquiline - Malancha Karmakar
- Oligomerisation and structural dynamics: New insights into native glycosylated apolipoprotein D - Claudia S. Kielkopf
- Investigating the role of conformation change in gating and conduction in potassium channels - Katrina Black
- The mechanism of IL-11 signaling antagonism by IL-11 Mutein - Riley Metcalfe
- Redesign and engineering the autotransporter β-barrel for enhanced stability and folding - Fergus Harrison
Dinner (own arrangements)
6:00PM - 7:45PM
Monday, 5th February
Session 6: Special Evening Lecture
7:45PM - 9:00PM
Monday, 5th February
Auditorium
Chair: Michael Landsberg
Sponsored by:
Session 7: Poster Session B - Including Happy Hour & Trade Display
9:00PM - 10:00PM
Monday, 5th February
Exhibition Hall
- Synthesis of novel 1,2,5-oxadiazoles and evaluation of their antibacterial action - Belinda M Abbott
- Deciphering the combinatorial complexity of Wnt-Frizzled interactions - Mark Agostino
- Structural basis of integrin antagonism by netrin-like domain-containing proteins - Mark Agostino
- Knowledge-based scoring functions for predicting carbohydrate-protein interactions - Mark Agostino
- Towards the first high resolution structure of Interleukin-11Rα - Kaheina Aizel
- DynaMut: Predicting the impact of mutations on protein conformation, flexibility and stability - David B Ascher
- Characterisation of a multimeric form of the periplasmic chaperone, SurA - Rebecca S Bamert
- Rational redesign of oxazolidinone antibiotics - Matthew Belousoff
- Characterization and redesign of pentatricopeptide repeat (PPR) - RNA binding proteins - Kalia Bernath-Levin
- A viral immunoevasin controls innate immunity by targeting the prototypical natural killer cell receptor family - Richard Berry
- Ab-initio Prediction of NMR Spin-Relaxation Parameters from Molecular Dynamics Simulations - Po-chia Chen
- MmpL3 is the flippase for mycolic acids in mycobacteria - Shu-Sin Chng
- Electron microscopy of human telomerase - Scott Cohen
- Combining Sense and Nonsense Codon Reassignment for Site-Selective Protein Modification with Unnatural Amino Acids - Zhenling Cui
- Defining the biochemical and intrinsic biological properties of the novel interferon, IFNε. - Nicole A De Weerd
- Calcium is essential for the iron-export activity of the ferroportin family - Chandrika Deshpande
- Ordered Stationary Phase Morphologies and their Effect on Mobile Phase Band Broadening in Chromatographic Systems - Fabian X O Dolamore
- Structural characterisation by Small Angle Scattering suggests models for monomeric and dimeric forms of the actin-cytoskeleton linker protein ezrin - Anthony P Duff
- New tools to study protein aggregation and the molecular chaperone action of heat shock proteins in cells. - Heath Ecroyd
- Structural characterisation reveals insights into substrate recognition by the Glutamine Transporter ASCT2 (SLC1A5) - Josep Font Sadurni
- Similarity and diversity of EF-G, EF4(LepA), and BipA in protein synthesis, and the LCIB in CO2-concentrating mechanism - Yong-Gui Gao
- 3.3Å phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex - Alisa Glukhova*
- The Structural Basis for Catecholate Uptake by the Ferric Iron Uptake (Fiu) Transporter from Escherichia coli - Rhys Grinter
- Fragment-based drug design using a fragment library designed for efficient hit-to-lead development - Menachem J Gunzburg
- Structure of a Pseudomonas aeruginosa toxin secretin - Iain D Hay
- Mapping the epitope for a monoclonal antibody derived from an autoimmune response against glutamic acid decarboxylase 65 - David E Hoke
- Phosphoproteomic analysis highlights at the cellular role of AMPK β1-Ser108 phosphorylation - Ashfaqul Hoque
- Structural basis for the Munc18 and Syntaxin interactions implicated for regulation of membrane trafficking - Shu-Hong Hu
- The inositol phosphate IP6 coordinates electrostatic pores to stabilise the HIV capsid and promote encapsidated DNA synthesis - David A Jacques
- Oxidative copper-enzymes are the key for unlocking recalcitrant biopolymers - Katja S Johansen
- MM-GBSA, Gaussian and electronic circular dichroism (ECD) determination of absolute configuration and binding efficacy of benzimidazole-based FabI inhibitors - Michael Johnson
- Structural studies of full length JAK1 - Nicholas PD Liau
- Insights into the structure, function, mechanism and evolution of sulfoquinovosidases - James P Lingford
- Go with the flow: reining in cofactors for continuous flow biocatalysis - Carol J Hartley